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KMID : 0363320010220020215
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Journal of Korean Oriental Internal Medicine
2001 Volume.22 No. 2 p.215 ~ p.222
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A Study on Activities of Antioxidant and Antimutagenecity of the Extracts from Gleditsia sinensis
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Lee Shin-Kyu
Shin Jeong-In
Seo Un-Kyo
Jung Ji-Chun
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Abstract
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Against the mutagen MNNG and NOPD with SOS chromotest, the antigenotoxic activity of MeOH-soluble extract was much more effective than that of the water-soluble one. When the extract was added to the certain concentration, the antigenotoxic acivity was enhanced. Against the mutagen NOPD with Ames test, the antimutagenic activity of MeOH-soluble extract was better than that of the water-soluble one. The 60.4% of the inhibition ratio for the revertant colony-forming unit was shown at 5 mg of MeOH-soluble extract per plate.
Antimutagenecity test with SOS chromotest and Ames test were performed using water-soluble and MeOH-soluble extracts from of Gleditsia sinensis. The antioxidant activity of MeOH-soluble extract with the NBT method was higher than that of the water-soluble one.
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KEYWORD
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MNNG and NOPD, antimutagenic activity, Gleditsia sinensis, antioxidant activity
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